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Research Translation Core
Applying toxicogenomics and biomolecular technologies
to
environmental monitoring, risk assessment and bioremediation
co-PIs
Dr. Keith Pezzoli
Dr. Ilya Zaslavsky
Superfund
Basic Research Program (SBRP) grant renewal (2005-2010)
SBRP Research Translation Core proposal
text (pdf file, 1.8m)
SBRP Research Translation Core letters
of support (pdf file, 21.0m)
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required
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SBRP
network |
SBRP science |
SBRP
org
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Research
Trans
Core relations |
Aims
mapped
Activities |
A selection
of images from the proposal, click thumnail for larger version.
Powerpoint file with the above images embedded into it, click
here
Research
Translation Core
Abstract
The Research Translation Core (RTC) of UC San Diego's Superfund
Basic Research Program (SBRP) has four specific aims: (1) Build
partnerships with government agencies and Tribal science labs to
advance the practical contributions of toxicogenomics in environmental
policy and planning; (2) Evaluate the utility of molecular biomarkers/biosensors,
microtechnologies and bioremediation as new biological models/methods
for improving environmental monitoring, risk assessment and remediation;
(3) Organize technology showcases, entrepreneurs/innovators forums
and educational workshops to foster the commercial development and
utilization of innovative SBRP technologies; and (4) Communicate
complex research findings to broad audiences through periodic workshops;
symposia; participation in regional, national and international
conferences; publications, and Web-based systems. The broad long-term
objective is to apply toxicogenomic knowledge and biomolecular technologies
to real-life problems concerning hazardous substances and environmental
health. Along these lines, biomarkers developed by SBRP scientists
will be evaluated, in partnership with the San Diego Baykeeper,
Tribal labs and government agencies responsible for water quality
monitoring, as potentially effective new cellular and analytic tools
for detecting Superfund toxicants in contaminated watersheds. At
the same time, SBRP-industry partnerships will promote the experimental
development and commercialization of novel bioremediation technologies
(e.g., transgenic plants that can hyper-accumulate heavy metals
out of contaminated soil), and microtechnologies (e.g., labs-on-a-chip
that can be used as biosensors for detecting exposure to pesticides).
The RTC’s approach leverages strong working partnerships and
information/visualization technologies already developed by the
Regional Workbench Consortium (RWBC) in partnership with the San
Diego Supercomputer Center. The RWBC was established as part of
UCSDs SRRP Outreach Core (2000-2005); it is a Web-based research
and learning network for sustainable development. The RTC’s
toolkit includes on-line geographic information systems (GIS), decision
support systems (DSS), multimedia interactive stories, and 3D visualization.
Click
here for the Community Outreach
Core
Click
here for details about the SBRP
grant renewal
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