SBRP RFA RELATED LINKS

Draft of the April 12, 2007 RTC/COC SBRP Seminar ppt file

Presently, the SBRP Program funds 19 university-based grants, for a total of 234 research projects and support cores (http://wwwapps.niehs.nih.gov/sbrp/index.cfm). The SBRP was established to complement the activities undertaken by the USEPA and the ATSDR:

The U.S. Environmental Protection Agency (EPA, http://www.epa.gov/superfund/index.htm)
The Agency for Toxic Substances and Disease Registry (ATSDR, http://www.atsdr.cdc.gov/)

Related Web sites with information on hazardous substances that are relevant to Superfund and to USEPA: http://www.epa.gov/superfund/resources/chemicals.htm and ATSDR http://www.atsdr.cdc.gov/clist.html.

Additional research topics and approaches of interest to the SBRP:
http://www-apps.niehs.nih.gov/sbrp/rfa/resources.html

National Institute of Environmental Health Sciences | Superfund Basic Research Program
A LEGACY IN MULTIDISCIPLINARY RESEARCH: Charting a Course for Advancing Basic Research to Practice
VOLUME 1: SBRP Technology Transfer and Information Transfer Tools (pdf file)

Superfund Program: Current Status and Future Fiscal Challenges
http://www.gao.gov/docdblite/details.php?rptno=GAO-03-850

SBRP proposal guidelines (from which the exerpts below were cut)
http://www-apps.niehs.nih.gov/sbrp/rfa/rfa_guidelines.html

Ecotox GIS! http://www.legacy.ca.gov/new_atlas.epl
Part of the California Digital Conservation Atlas, a Joint Effort of OEHHA and the California Legacy Project. Ecotox GIS is a new product of the Ecotoxicology Unit, whose goal is to develop scientific and technical resources and tools for ecological risk assessment

The Ecotoxicology Unit was formed within the Cal/EPA Office of Environmental Health Hazard Assessment (OEHHA) in response to increasing needs in California for the specific assessment of ecological risks posed by chemicals. Current activities in the Ecotoxicology Unit support development of general ecological risk assessment guidelines and technical resources for Cal/EPA.
http://www.oehha.ca.gov/ecotox.html

Bioremediation, click here

Biomarkers, click here

Water Quality Monitoring, click here

PUBLICATIONS:

Author Anderson, J.W., J.M. Jones, J. Hameedi, E. Long, R.H. Tukey
Title Comparative analysis of sediment extract from NOAA's bioeffects studies by the biomarker P450 reporter gene system. Journal Title Marine Environmental Research. Publication Information 1999. http://www6.nos.noaa.gov/noslib/pubdisplay.lasso?-KeyValue=33136&-Token.Action=

Abstract
Sediment samples collected from nine coastal and estuarine areas have been analyzed to determine response of a biomarker, P450 Reporter Gene System (RGS). This biomarker, using a transgenic cell line, detects the presence and potency of organic compounds that typically induce the CYPIA gene. Previous investigations have shown that sediments containing chemicals which produce a response of 60 or more ug/g of benzo[a]pyrene equivalents (B[a]PEq) also exhibited a degraded community structure. RGS data from all study areas combined (527 samples) show that the mean response is 22.7 ug/g B[a]Peq, and the mean upper 99% confidence interval is 32. We believe that sediments exhibiting B[a]PEq values of 32-60 are possibly contaminated to the extent that effects on benthic organisms may be observed, and those producing an RGS response of 60 and greater are likely to contain levels of chemicals that will produce chronic toxicity. The majority of the stations investigated produced responses below 32ug/g B[a]Peq. No samples from coastal southern California produced responses greater than 39. However, samples producing induction over 60 ug/g B[a]Peq were:50%, San Diego Bay;16%, Delaware Bay; 8%, Sabine Lake; 4%, Northern Puget Sound; and 3%, Charleston Harbor. A strong statistical correlation was observed between the RGS responses and high molecular weight polycyclic aromatic hydrocarbon concentrations in the sediments from several of the study area. Of the 2694 km2 encompassed in the surveys, only 0.42% of the area exhibited responses above 32 ug/g B[a]Peq, which represented 11.4 km2. This assay is useful in identifying high levels of toxic and carcinogenic compounds in the sediments and predicting the potential impact of these chemicals on the biological community. This work was supported by NOAA's National Centers for Coastal Ocean Science, Center for Coastal Monitoring and Assessment.
Keywords: comparative analysis, bioeffect studies, biomarker P450, reporter gene system, RGS, Center for Coastal Monitoring and Assessment, CCMA

Editor: Wilson, Samuel H., 1939-
Title: Biomarkers of environmentally associated disease : technologies, concepts, and perspectives / [edited by] Samuel H. Wilson, William A. Suk
Publisher: Boca Raton : Lewis Publishers, c2002

Bay, S.M., D. Lapota, J. Anderson, J. Armstrong, T. Mikel, A.W. Jirik, and S. Asato. 2000. Southern California Bight 1998 Regional Monitoring Program: IV. Sediment Toxicity. Southern California Coastal Water Research Project. Westminster, CA.

Sediment extracts from 268 stations were evaluated for toxicity using the P450 human reporter gene system (HRGS) test, which measures the concentration of organic compounds that induce the cytochrome P450 enzyme system (e.g., PAHs, dioxins, furans, and some PCBs).
ftp://www.sccwrp.org/pub/download/PDFs/bight98sedtoxrpt.pdf

NIEHS SBRP | Volume I
Journals Most Frequently Published in by SBRP Scientists (1995-2002*)
TOTAL SBRP PUBLICATIONS by JOURNAL
Environmental Health Perspectives ­ 156
Environmental Science & Technology ­ 136
The Toxicologist ­ 101
Toxicological Sciences ­ 93
Toxicology and Applied Pharmacology ­ 85
Environmental Toxicology and Chemistry ­ 79
Applied and Environmental Microbiology ­ 58
Carcinogenesis ­ 52